If you can still use a mouse well, grand strategy games can be played with one hand. Despite all the (deserved) criticism they get, paradox games are a lot of fun. (and their modern ones even feel like a full game without having to buy any dlc) They can be a bit difficult to keep up with without a keyboard though so play on lower speeds.
If you are more concious about who you give your money to, endless legend 2 is a 4x published by hooded horse that is very good (think civ but fantasy) and since it is turn based it is a lot easier to play with just a mouse.
Any points and click adventure game, there are loads including old classics and modern good games.
Monkey Island remasters are fun and can be played with mouse. Broken Sword games are also good.
Rusty Lake games are great if you prefer more puzzle games than narrative ones. Still has a great somewhat surreal plot just not like a point and click narrative game.
Also If you havent played dwarf fortress now is the time to learn, the siege update came out this week. Mouse or keyboard, or both, but definitely can be done one handed.
Vampire Survivor that others have suggested is a good shout, one hand on the keyboard is enough and its very addictive.
If you have a joystick or wheel, flight Sims, space sims, racing games might be possible.
RTS games in single player mode (just play on an easier difficulty). Plenty of decent ones have been released in the last little while. Also, maybe 4x games, total war etc.
Sins of a Solar Empire. It’s a space based strategy game that I’ve sunk hours into. years ago I used to have really shotty internet so it would go down all the time. I’d play that game for 8 hours a pop easily and the time would just fly by. I’m not even a big strategy gamer but I adored that game.
Shapez or shapez 2 are really good factory games that dont really require a lot of thumb movement, else play the west of loathing, this one is fantastic turn styled rpg rame where you go west after the cows came home, also there is a spittoon, you can reach into it, and have the narrator describe the horrors you feel whilst poking around in there to fish out a assortment of spit infused garbage to wear on your person
The menu inputs require both hands on console, if it wasnt for that its pretty good for it. I played it a lot when I was holding my baby, bottle in one hand and controller in the other.
Does this actually get in the way when you’re playing with mouse and keyboard? I do use my non-dominant thumb for hitting the space, alt and strg keys, but in many games that’s kinda optional, especially when the games aren’t super challenging. Turn-based RPGs like Divinity: Original Sin or Baldur’s Gate 3 should work great.
I mean if it’s wasd then yes, idk maybe I could do some fighting side scrollers but I’m also really trying to baby this thumb so possibly might be a bad idea to get worked up
Monument Valley 1, 2, and 3 (mobile games). An interesting set of puzzle games with good visuals. They only require single taps to work.
Also can get a mouse for the Steam Deck (or a PC if you have one). There are a lot of good games that you can likely use with a mouse if the hand/wrist motion doesn’t cause pain or discomfort for your thumb.
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