I tried to mod Cyberpunk 2077 and it was not a smooth experience. I first tried using Vortex in Bottles but it wouldn't run. I then tried to use ProtonUp-QT but couldn't figure out exactly what to do. I discovered that there's a new NNM AppImage that's early in development that works with Cyberpunk.
I'll have to try again in the future and figure out how ProtonUp-QT, ProtonTricks, Steam Tinker Launcher, etc.