I like how in Breath of the Wild, when it tells you to a button like ‘A’ or ‘Y’ for example, it shows you where that button is relative to the others. This way, if you aren’t super familiar with the controller, you don’t need to take your eyes off the screen.
First thing that came to mind was FTL: Faster Than Light. I used to play on a laptop with no mouse and a lousy touchpad, so I became familiar with the hot-keys.
You can pause the game at any point to stage your attack / defense. Most commands have hot-keys you can press, rather than point and clicking. You might need to use the mouse for a few parts, but given the ability to always pause the game (I think it’s game mechanic really) you shouldn’t have too much trouble since you’re under little pressure to do so quickly.