Inscryption is an interesting story designed around an interesting card game, and it ends when you finish the story. The devs other games work with this game to build a deeper world (The Hex, Pony Island, etc), and the lore of Inscryption goes pretty deep too, so look on YouTube for a breakdown once you finish and your mind will be blown.
Slay the Spire is a roguelike with a bit deeper mechanics, but incredibly shallow story (if you can call it that). There are multiple classes with different play styles, and you will likely take a different strategy each run depending on what cards you see.
I highly recommend both, but it depends on what excites you more, interesting story or replayability. Inscryption has horror elements in the storytelling, Slay the Spire is basically just a weird fantasy theme.
My preference is Inscryption, but I’m more into story than gameplay, all else being equal. Both are solid.
GerardsGuitar