Which typically culminates in rolling up everyone on Earth by the time you get to the final stage, no less. If that’s not a group hug, I don’t know what is.
Edit: I’m also going to second the Psychonauts recommendation, especially the second game. Despite the gameplay itself inevitably lending itself to the protagonist performing every little bit of work by himself, there are strong themes of teamwork all throughout the game’s story and the excellence of its final sequence cannot be understated:
To your edit, similarly the final sequence of Nier Automata is so deeply rooted in not being alone, and encouraging one another, and being there for one another. A chance to break the cycle.
Midnight Suns is perfect for you. It’s part team tactical deck building combat, part superhero relationship simulator. You alternate between fighting evil as part of a squad of heroes (the DLC includes Deadpool) and spending time hanging out and talking with other heroes. And it’s just a phenomenal game all around.
So I’m not sure what might make you not feel lonely or anxious. Things like how directly you control the characters with you could he factors I imagine, so I’m just going to list a bunch of things:
A shorter one, but Star Wars Republic Commando. You’re a commando unit and work as one.
Dragon’s Dogma, either Dark Arisen or the new sequel.
Mass Effect series.
I don’t know if Earth Defence Force would be like that or not, at the end of the day your NPC allies could be hit or miss (literally, depending on the weapons you use).
Not sure how you feel about party-based RPGs, but there are tons of them.
I’m wondering if RTS games with campaigns would feel right as well. StarCraft’s campaigns have a lot of people constantly talk to/around you.
The Lego games?
Stardew Valley?
Can’t really think of indie games at the moment.
Games I haven’t played so I don’t know if they apply: Persona? Space Marine games?
You could try a Persona Game (or the new Metaphor) These games are build on your relationships with the other characters. They think of you, they contact you often on their own because they want to do something with you. You just have to like to read. Those things are half JRPG, half Visual Novel.
One of the power ups you can buy is literally to dispense friends (options) which follow you around and shoot alongside you. You can crank out as many as you want, at least within reason. And in some of the Parodius games they are literally little dudes. Or depending on your character, little octopi, cats, or penguins.
RPGs come immediately to mind. Your partner in Disco Elysium is more competent than the main character for reasons that will be immediately obvious. Bethesda’s RPGs are also open world, and while you’ll start out alone in them, you get permanent companions pretty quick (especially if you know where to look). They also get more chatty in the world and more character development in the later games. Fallout 4 more so than Skyrim more so than Fallout 3, for example. Starfield makes you swap them out if you do the main story, which I don’t know if you’ll like or not.
For a dedicated shooter, I think Titanfall 2 has the most protective companion I’ve seen in the genre. Get this one on sale, since it has its robust multiplayer priced in, but it has an excellent–if a bit short–single-player campaign.
Cult of the lamb - build a cult?
Sky - a cutesy online exploration game that pppl team up in. I know it's not single-player - but it's kinda singlemulti?
“Binary Domain” is an option. You are almost all the time accompanied by 1-3 NPCs of your Team. The game also has a, more or less working, voice System to talk to your team through your microphone. That way you can give orders and have some small talk. The game is quite good, give it a try.
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