I've gotten away with even harder to run games on a HDD but even if it is on an SSD, I've found it to be inconsistent plus only BG3 acts up compared to everything else I have going.
The biggest requirement, imo, is probably just having an SSD for the game. There's a LOT of pop ins and textures that just don't load until a few minutes later. It does have a "slow HDD mode" but it hasn't really done much from what I can see.