I remember that when Star Trek Online was first announced, it was VERY different than what it is now... and it actually more closely resembled what you were describing. Each character would be free to do some of their own hero stuff in the galaxy but also be on 'hub ships' where you were a smaller part of a much larger whole, participating in shipboard stuff. Then it changed hands or somesuch, and the new leadership said, "Nobody just wants to be some random person on a starship! Everyone wants to be the captain!"
To which I said, "No, actually... ._. I think I would enjoy just vibing on a supercool space ship with my Fully Automated Luxury Gay Space Communism lifestyle." So it would be interesting to see someone try to do STO as it was originally intended.
A strategy/management sim where you are a Madam running a brothel. Lots of ways to take it-- set it in different places/eras to signify how far under the radar you have to be, change your regime from harsh to compassionate, build out the brothel itself, recruit talent (ethically or unethically), decide if you want to theme the establishment to attract a certain clientele-- lots of interesting things you could do with the setting!