That hasn’t really been my experience. If you just want to play the game you can stick to the performance, anti-crash, stability and bug fix mods and have a very stable game.
Learning to expand your load order beyond that can be exhausting (and probably takes some work in Wrye Flash and xEdit), but I played through the entire campaign and all DLCs last year with like 400+ mods and had no crashes and only one real bug.
Rheios
ayaya