What actual genre do you like to play? Might get some more relevant recommendations. Otherwise, top-down is just a POV and there are a ton of genres that have been made this way.
Factorio - Factory Building
Door Kickers - Tactical CQB
Dwarf Fortress - Roguelite Town Management
The Battle for Wesnoth - Turn-based RPG
GTA1/2/London 1969 - The best GTAs
FTL - Roguelite space adventure. Real-time with pause.
You could try of The Devil! It’s an episodic indie cyberpunk courtroom mystery game and the first episode is free. (also i’ve been obsessed with it lately and need more people to talk about it pls pls pls)
2 very different genres, since you didn’t specify:
FlatOut 2 is a fun, fast-paced arcade racing game that can be played with one hand. You just need the cursor keys and Ctrl for Nitro.
In Papers Please, you work at a Soviet-like country’s border crossing and have to check every immigrant’s details while making difficult moral decisions under time pressure. Mouse only.
I don’t see any mention of the Civilization games. Civ III is my personal favorite but Civ V was also good. Keyboard shortcuts are a little bit quicker of course but it’s turn based so there’s no rush!
A lot of RTS games play fine with just the mouse, especially in the early stages of playing. I’ve seen a few mentioned but I’ll put Stronghold Crusader onto the recommendation list. I generally play it without any keyboard inputs.
Voidigo is pretty unique I think. Chaotic roguelite with unique and sometimes asinine weaponry. Sure, it can sometimes feel a bit like Enter the Gungeon, but I feel the art style separates it a good bit from that and other top down shooters. Plus the guns and melee can be a bit crazy in their own right.
I appreciate that I can avoid tolls and highways with Mapquest Directions. The ability to customize my route makes it feel like I’m really in control of my trip.
Great tool for parents and grandparents! My mom still prints MapQuest directions and finds it much easier than using her phone or car GPS.
I never thought I’d return to MapQuest, but it actually came through when Google Maps failed me during a low-signal drive through rural areas.
Slay the Spire - a roguelike deckbuilder is a lot of fun.
I haven't actually tried it, but Balatro has made a lot of waves recently and I imagine you could play that with only mouse.
Also, what kind of mouse are you using? If you're still on a no thumb buttons mouse, you should definitely upgrade. If you only have 2 thumb buttons, as is most common, I'd recommend looking at something with more. My mouse has 3 thumb buttons, and two extra index finger buttons. logitech g502 and while some people like that mouse (i do) some don't, so I can't say whether you'd like it, but I will say the extra buttons have allowed me to set up a lot of games that would normally require a keyboard as well into a more mouse only friendly experience.
This one feels a bit more like Risk in space and I never got on with Risk, or in fact any of the Civ series of games, which this also reminds me of a bit. I sort of meant top down in the Desperadoes 3 style but I'm totally open to other ideas :)
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