The last time I played Cyberpunk, it was actually good fun. Game was a bit empty, and it was pretty obvious they'd been forced to cut a lot of stuff, but I played it for several hundred hours without too many bugs. Pretty and ran well on my budget pc too.
Same, but realistically once you start heading towards the 500 mods range, it's almost impossible to get it working reliably.
At one point I had 200+ mods on skyrim, and the mod cycles and before/after conflicts on vortex looked like mandelas. I did enjoy 'completing' the vortex mod manager game. That's when it's 3AM, you're fed up, you give up trying to figure what's wrong, and just click randomly and uninstall/reinstall mods until vortex shuts up, and it somehow just works. Bit like winning the lottery.
Don't know how much free time you have, but I couldn't be bothered anymore for FO4 on nexus. I just downloaded one of the bigger/better collections and ignored/deactivated the creepier/boobier mods.
Already more than enough of a hassle to get that working, with vortex sometimes not installing stuff properly, pre-cleaning files, etc.
This game will run fine on a 2080, by the time it's been fully patched and optimised by the modding community. Honestly, can't wait till 2025 when I'll be able to play the finished game.