I rarely replay games, but this is one I fully intend to replay with a different/bigger party (currently playing with one friend, but I’m gonna get two more to buy the game for the next run), a different class (currently playing cleric, thinking about barbarian or bard) and on the highest difficulty.
I think you technically miss quite a lot of content as some choices make other things impossible to pursue. I also take it as it comes, by that I mean I don’t reload save states because I failed a dice throw or made mistakes.