Not exactly the same but sort of related: the first time I played the New Vegas DLC Honest Hearts, I accidentally shot a character that is meant to be a companion, turned him and essentially all quest characters hostile and basically forced the game to direct me from the opening of the DLC to the final mission because I couldn’t do anything to side with anyone. I thought it was the shortest most bullshit DLC with not nearly enough to do for at least a few years before I played it again and realized how much I missed.