I really wanted to like this one. On paper it sounds like exactly my jam, but it just didn’t grab me. The whole game felt tedious. Mediocre combat, very little weapon variety (just different tiers of the same kind of gun). Finicky and overcomplicated skill system that still somehow didn’t feel like it made any impact on core gameplay, and I found the humour kind of simultaneously weak and overdone. The satire is heavy-handed, and the wackiness falls flat. I haven’t enjoyed a fallout game since 3 either though, so maybe my taste has changed without me realising.
Story wise it’s self contained. You might be on slightly better footing with the building mechanics if you’ve played another, but it’s different enough that it’s not required.