Some of my other picks have already been mentioned so I’ll go with an obscure answer: Cpt. Olivia Rhodes from the VR game Lone Echo.
She is by far the most realistic and immersive NPC I have ever had the fortune of experiencing. The storytelling and immersion in Lone Echo is S tier. The game itself is in my top three VR games with Half-Life Alyx and Boneworks.
It’s only awful if you’re achievement hunting and trying to drive the god damn gnome through the level without it flinging off into space and being lost forever